Specific inhibitors of tissue kallikrein
US4835253A · kind A · utility
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16Claims
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Key dates
| Filing date | Apr 3, 1987 |
| Grant date | May 30, 1989 |
| Priority date | — |
| Expiry date | Apr 3, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0812
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A unique class of tissue kallikrein inhibitors is provided which are specific for tissue kallikreins and do not substantially cross-react with plasma kallikreins or other serine proteases in-vivo. These inhibitors are substrate analogues of low molecular weight kininogens but are highly inhibitory, stable and resistant to enzymatic hydrolysis, and release non-toxic degradation products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.