Preparation of piperidinylcyclopentylheptenoic acid derivatives
US4835278A · kind A · utility
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22Claims
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Key dates
| Filing date | Jan 28, 1987 |
| Grant date | May 30, 1989 |
| Priority date | — |
| Expiry date | Jan 28, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/155
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for the preparation of a compound of formula (2) ##STR1## (wherein R is a C.sub.1-6 alkyl or a C.sub.7-20 aralkyl group) and the salts thereof, which comprises reducing a compound of formula (3) ##STR2## (or a salt thereof), using a reducing system comprising borohydride ions and metal ions selected from lanthanide ions, alkaline earth metal ions or yttrium ions in solution. The reduction system may be provided by a borohydride (e.g. NaBH.sub.4) and a metal salt (e.g. CeCl.sub.3). The ester (2) may then if desired be hydrolyzed to give the parent acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.