Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles

US4835280A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Alfred Martens · Schriesheim, DE
• Jens-Peter Holck · Mannheim, DE
• Herbert Berger
• Bernd Muller-Beckman · Herxheim, DE
• Klaus Strein · Hemsbach, DE
• Egon Roesch · Mannheim, DE

Key dates

• Filing date: Jul 14, 1987
• Grant date: May 30, 1989
• Expiry date: Jul 14, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.