Pharmacologically active compounds and use
US4837203A · kind A · utility
1Cited by
2References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 7, 1987 |
| Grant date | Jun 6, 1989 |
| Priority date | — |
| Expiry date | Jul 7, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The peptides of the formula EQU X--Tyr--X.sup.2 --Gly--Phe(4NO.sub.2)--Pro--NH.sub.2 wherein X is hydrogen or an amidino group and X.sup.2 is D-S-methylmethionyl or D-arginyl, together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in reversing neuronally-mediated bronchoconstriction in mammals. The said compounds have application in the palliation of conditions characterized by such a state, in particular asthma in human beings.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.