Penem derivatives

US4837215A · kind A · utility

Assignee

• Farmitalia Carlo Erba S.p.A. · IT

Inventors

• Ettore Perrone · Milano, IT
• Marco Alpegiani · Milano, IT
• Angelo Bedeschi · Milano, IT
• Franco Zarini · Milano, IT
• Giovanni Franceschi · Milano, IT
• Costantino D. Bruna · Rho, IT

Key dates

• Filing date: Apr 8, 1986
• Grant date: Jun 6, 1989
• Expiry date: Apr 8, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the following formula I ##STR1## wherein X represents a sulphur or an oxygen atom, PA0 R is hydrogen or a C.sub.1 -C.sub.4 alkyl group either unsubstituted or substituted by one or more substituents chosen from a free or protected hydroxy group and halogen atom; PA0 A is a Z, Z--O--CO-- or --Z--CO-- residue, wherein PA0 Z represents PA1 (a) an optionally substituted phenylene or naphthylene group, PA1 (b) an optionally substituted heterocyclediyl radical wherein the hetero ring is mono or bicyclic, saturated or unsaturated containing at least one heteroatom selected from the group of oxygen, sulphur and nitrogen; PA1 (c) an optionally substituted linear or branched C.sub.1 -C.sub.7 alkylene radical; PA1 (d) a C.sub.2 -C.sub.4 alkenylene or alkynylene group or a group of formula ##STR2## (e) an optionally substituted C.sub.3 -C.sub.8 cycloalkylene ring; (f) an aralkylene radical of the formula ##STR3## wherein n is 1, 2 or 3; and PA0 Q.sup.(+) represents a +NR.sub.1 R.sub.2 R.sub.3 group, wherein PA1 (i) R.sub.1, R.sub.2, R.sub.3, are each independently an optionally substituted alkyl, aralkyl or aryl radical; or p1 (ii) R.sub.1 is as defined above under (i) and R.sub.2…