Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4837239A · kind A · utility
41Cited by
25References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1986 |
| Grant date | Jun 6, 1989 |
| Priority date | — |
| Expiry date | Oct 14, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to a formulation of cardiotonic phosphodiesterase inhibitors with a water-soluble vitamin, comprising a lyophilization step performed on a solution of the complex in an aqueous/organic solvent system. The formulation results in a complex that has been found to have enhanced solubility (over the compound alone) in a parenterally or orally acceptable solvent, and the lyophilization process yields a product with superior stability permitting an extended shelf life.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.