Napthoquinone antibiotics from fuserium solani
US4837399A · kind A · utility
6Cited by
2References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 10, 1988 |
| Grant date | Jun 6, 1989 |
| Priority date | — |
| Expiry date | May 10, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/929
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Three naphthoquinones isolated from cultures of Fusarium solani were found to be effective antibiotics against gram-positive bacteria. Controlling the dissolved oxygen concentration in the fermentation medium between 0.7 and 2.0 ppm resulted in maximum yields of the naphthoquinones. 2,3-Dihydro-5,8-dihydroxy-6-methoxy-2-hydroxymethyl-3-(2-hydroxypropyl)-1, 4- naphtholenedione was the most effective antibiotic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.