Eburnamenine derivatives, pharmaceutical compositions and methods employing them and processes for their preparation
US4839362A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 18, 1986 |
| Grant date | Jun 13, 1989 |
| Priority date | — |
| Expiry date | Apr 18, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) ##STR1## or (Ib), ##STR2## wherein R.sub.1 stands for a C.sub.1-4 alkyl group; and PA1 R stands for hydrogen, a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, an acyl or substituted acyl group, as well as their acid addition salts, of which the trans compounds are novel. The invention also relates to the compounds of the general formula (IIIa) ##STR3## and (IIIb), ##STR4## wherein R.sub.1 and R' represent a C.sub.1-4 alkyl group. The compounds of the general formulae (Ia) and (Ib) possess a vasodilatory effect which is substantially higher than that of pentoxifyllin, a known peripheral vasodilator.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.