Substituted azabicycloalkanes, the use thereof, pharmaceutical compositions containing them
US4839379A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1987 |
| Grant date | Jun 13, 1989 |
| Priority date | — |
| Expiry date | Jul 28, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C205/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-Phenyl-3-azabicyclo[3.1.0]hexane-2,4-diones of the formula ##STR1## wherein R.sub.1 is hydrogen, R.sub.2 is hydrogen, sulfo or acyl and R.sub.3 is hydrogen, or R.sub.1 is a saturated or unsaturated aliphatic, cycloaliphatic or cycloaliphatic-aliphatic carbon radical of up to and including 18, preferably of up to and including 12, carbon atoms, R.sub.2 is hydrogen, lower alkyl, sulfo or acyl and R.sub.3 is hydrogen or lower alkyl, and to salts thereof, and salts thereof, have valuable pharmacological properties and are effective aromatase inhibitors. They can therefore be used for the treatment of hormonal diseases, in particular mammary carcinomas.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.