1-(hydroxystyrl)-5H-2,3-benzodiazepine derivatives, and pharmaceutical compositions containing the same
US4840948A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 20, 1987 |
| Grant date | Jun 20, 1989 |
| Priority date | — |
| Expiry date | May 20, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R stands for a hydrogen or halogen atom, or a C.sub.1-4 alkoxy group, PA1 R.sup.1 represents a hydrogen atom or a C.sub.1-4 alkyl group, PA1 R.sup.2 and R.sup.3 are identical and denote a C.sub.1-4 alkyl group, or combined they denote a methylene group. The compounds of the general formula (I) possess valuable positive inotropic (cardiotonic) potency, are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.