1-t-butyl ergolines useful in the treatment of cerebral insufficiency and senile dementia

US4843073A · kind A · utility

Assignee

• Farmitalia Carlo Erba S.p.A. · IT

Inventors

• Aldemio Temperilli · Milano, IT
• Enzo Brambilla · Mariano Comense, IT
• Mauro Gobbini · Somma Lombardo, IT
• Maria A. Cervini · Cardano al Campo, IT

Key dates

• Filing date: Jun 23, 1987
• Grant date: Jun 27, 1989
• Expiry date: Jun 23, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

t-Alkyl ergoline derivatives of formula I are produced ##STR1## wherein (R.sub.1 =H, OCH.sub.3 and R.sub.2 =H) or (R.sub.1 +R.sub.2 =a ring bond and R.sub.3 =H, optionally substituted nicotinoyl or 1-oxo-2-cyclopenten-3-yl); and their pharmaceutically acceptable salts. A process for the preparation of these derivatives from lysergol and a t-alkyl alcohol is also described, as are pharmaceutical compositions containing them.