Aryl and heteroaryl substituted cycloalkyl compounds
US4843081A · kind A · utility
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4Claims
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Key dates
| Filing date | Jun 27, 1988 |
| Grant date | Jun 27, 1989 |
| Priority date | — |
| Expiry date | Jun 27, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
##STR1## and pharmaceutically acceptable salts thereof, wherein: Ar is phenyl, naphthyl, heteroaryl, indole, or fused arylcycloalkyl optionally substituted with hydroxy, halo, CF.sub.3, NO.sub.2, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or aryloxy; PA1 A and A' are each hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or aryloxy; PA1 X is cyano, nitro, COOR, SR, SOR or SOOR; PA1 R is H, C.sub.1-6 alkyl or aryl; PA1 n n' and n" are each 0 to 4; and PA1 m, m' and m" are each 1 to 4, have calcium channel blocking activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.