Immunologically active polypeptides useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies
US4843146A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 3, 1987 |
| Grant date | Jun 27, 1989 |
| Priority date | — |
| Expiry date | Dec 3, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunologically active polypeptides constituted, towards the N-terminated end, by an Asn-Val-Asp-Pro-Asn-Ala-Asn-Pro sequence repeated three times and, towards the C-terminated end, by at least three quadruplets with an Asn-Ala-Asn-Pro sequence, linked with each other by means of an amidic bond between the end proline of the first sequence, and the initial asparagine of the first quadruplet. Said polypeptides reproduce nearly exactly the sequential structure of the circumsporozoite protein of P. falciparum, and are useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.