Assay systems for detecting cell-free T cell antigen receptor related molecules and the clinical utilities of the assays
US4845026A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 3, 1985 |
| Grant date | Jul 4, 1989 |
| Priority date | — |
| Expiry date | Dec 3, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/827
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for detecting and determining the amount in a sample of an antigenic determinant from an antigen receptor derived and released from a T cell or NK cell. Methods are also provided for detecting and determining the amount in a sample of an antigenic determinant from a complex of at least a portion of an antigen receptor derived from and released from a T cell or NK cell and a protein complex. These methods form the bases for methods of diagnosing and monitoring in a subject a disease characterized by the presence or an amount different from a normal subject of one of these antigenic determinants in a body fluid. A soluble antigen receptor or complex thereof derived from a T cell or a NK cell but free of such T cell or NK cell is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.