Biologically active B-chain homodimers
US4845075A · kind A · utility
85Cited by
4References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 15, 1986 |
| Grant date | Jul 4, 1989 |
| Priority date | — |
| Expiry date | Dec 15, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/221
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the B-chain of PDGF. Alternatively, the protein may have two polypeptide chains that are substantially identical to the B-chain of PDGF. In addition, proteins comprising polypeptides that are variants or derivatives of the B-chain of PDGF are also disclosed. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.