Diaryl substituted cyclopentane and cyclopentene derivatives

US4845129A · kind A · utility

Assignee

• Sandoz Pharm. Corp. · US

Inventors

• Robert C. Anderson · Lake Hopatcong, US
• William J. Houlihan · Baden-Baden, DE
• Howard C. Smith · Plainsboro, US
• Edwin Bernard Villhauer · Morristown, US

Key dates

• Filing date: Mar 14, 1988
• Grant date: Jul 4, 1989
• Expiry date: Mar 14, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated broncho-constriction and extravasation, PAF-induced hypotension, PAF-induced ischemic bowel disease and PAF-mediated, endotoxin induced lug injury.