Glucose-6-phosphate dehydrogenase conjugates useful in polyiodothyronine assays
US4847195A · kind A · utility
18Cited by
7References
11Claims
0Family size
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Key dates
| Filing date | Nov 24, 1987 |
| Grant date | Jul 11, 1989 |
| Priority date | — |
| Expiry date | Nov 24, 2007 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/78
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Polyiodothyronine analog conjugates to glucose-6-phosphate dehydrogenase (G6PDH) are provided which find use in the determination of polyiodothyronine compounds, particularly thyroxine, normally in physiological fluids, such as serum. The G6PDH enzyme activity can be substantially reduced when bound to antibodies specific to polyiodothyronine as compared to the free or unbound polyiodothyronine analog enzyme conjugates. The polyiodothyronine analog is conjugated to the G6PDH by a linking group having a chain one atom in length.
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