Conjugation of polymer to colony stimulating factor-1
US4847325A · kind A · utility
238Cited by
20References
26Claims
0Family size
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Key dates
| Filing date | Jan 20, 1988 |
| Grant date | Jul 11, 1989 |
| Priority date | — |
| Expiry date | Jan 20, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.