Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor
US4847384A · kind A · utility
3Cited by
4References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1987 |
| Grant date | Jul 11, 1989 |
| Priority date | — |
| Expiry date | Mar 12, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An improved process for preparing certain nitrogen-containing mono- and bicyclic ACE inhibitors comprising reacting an .alpha.-alkyl amino acid with a disulfide compound to form a thioester intermediate, which intermediate is then amidated with a mono- or bicyclic amino acid. The invention also relates to the novel thioester intermediates prepared by the first step of the process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.