Droplet freezing method and apparatus
US4848094A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1988 |
| Grant date | Jul 18, 1989 |
| Priority date | — |
| Expiry date | Apr 29, 2008 |
Classification
- Technology area (CPC F)Mechanical Engineering; Lighting; Heating
- CPC primaryF25C1/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method and apparatus for the generation of essentially spherical frozen droplets of a liquid biological or organic-comprising composition. The liquid composition if fed under positive pressure through a nozzle in a manner which provides a continuous stream of the liquid composition exiting the nozzle; the continuous stream travels through a gas or vapor for a distance sufficient to cause the continuous stream to break apart, forming droplets ranging in size from about 0.6 mm to about 5 mm; the liquid composition droplets are then contacted with a cryogenic liquid capable of freezing the droplets into a solid phase; the frozen droplets are concentrated into a portion of the contacting cryogenic liquid from which they are subsequently separated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.