Diels-alder adduct from streptazoline and naphthoquinones and its oxidation products, which have cytotoxic and antimicrobial activity and which act against protozoa

US4849409A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans-Ullrich Hoppe · Hofheim, DE
• Susanne Grabley · Königstein, DE
• Hartmut Voelskow · Hattersheim, DE
• Merten Schlingmann · Königstein, DE
• Hans Kraemer · Marburg, DE
• Matthias Wiesner · Seeheim-Jugenheim, DE
• Joachim Thiem · Hamburg, DE

Key dates

• Filing date: May 12, 1987
• Grant date: Jul 18, 1989
• Expiry date: May 12, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.