Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
US4851419A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1986 |
| Grant date | Jul 25, 1989 |
| Priority date | — |
| Expiry date | Oct 14, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are described compounds of formula I, ##STR1## in which A is a benzene or heterocyclic ring, y is 0 or 1, PA1 L is a group containing 1 or 2 carbon atoms, or is a single bond, PA1 R.sub.9 and R.sub.10 have a variety of significances, e.g. PA1 R.sub.10 may form part of a double bond with L, or PA1 the group --NR.sub.9 R.sub.10 forms a ring carrying substituents R.sub.1 and R.sub.8, or PA1 when L is a single bond --NR.sub.10 and R.sub.8 may form a ring carrying substituents R.sub.16 to R.sub.25, or PA1 the group --LNR.sub.9 R.sub.10 forms a heterocyclic ring carrying substituents R.sub.26 to R.sub.33, PA1 R.sub.1 to R.sub.8 and R.sub.16 to R.sub.33 have a variety of significances PA1 n is 0, 1 or 2, PA1 x is 3, 4 or 5, PA1 X is S, O or NR.sub.15, PA1 R.sub.15 is hydrogen, --COR, --COOR or alkyl optionally substituted by --OCOR, PA1 and certain provisos. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions involving excess gastric acid secretion, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.