Pharmaceutically active compounds
US4851423A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1986 |
| Grant date | Jul 25, 1989 |
| Priority date | — |
| Expiry date | Dec 10, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The disclosed invention is compounds represented by the formula EQU Z--X--Q--Y--W, I EQU Z--X--Q--Y--W'--Y--Q--X--Z II and pharmaceutically acceptable acid addition salts and quarternary amine salts thereof, wherein PA1 Z is phenyl, naphthyl or adamantyl; substituted phenyl wherein the substituents are one or more of halogen, lower alkoxy, phenoxy, nitrile, nitro, phenylsulfonyl, methylsulfonyl, isoxazol-2-yl, lower alkanoyl, benzoyl, lower alkoxycarbonyl, lower alkyl, loweralkylthio, phenyl, phenylaminothiocarbonyl, or lower alkylaminothiocarbonyl; 5 or 6 membered unsubstituted or substituted heterocyclic ring containing at least one nitrogen and one carbon in the ring, wherein the substituents are one or more of carboxyl, hydroxymethyl, loweralkyl, loweralkylcarbonyl or aryl lower alkyl; or tertiary butyl; PA1 X and Y are each independently a bond, -O-, ##STR1## Q is a divalent substituted or unsubstituted straight or branched chain lower alkanediyl, -lower alkanedinyl- cycloalkanediyl- lower alkanediyl-, lower alkendiyl, lower alkynediyl, phenylene, tetrahydrofurandiyl or tetrahydropyrandiyl; PA1 W is a monovalent substituted or unsubstituted aromatic heterocyclic single or fuse…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.