1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy
US4851424A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 26, 1987 |
| Grant date | Jul 25, 1989 |
| Priority date | — |
| Expiry date | May 26, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-Phenyl-lower alkylimidazole-4- and/or 5-carboxamides of the formula ##STR1## in which Ph represents phenyl substituted by lower alkyl and/or by halogen, alk represents lower alkylidene, one of the radicals R.sub.1 and R.sub.2 is carbamoyl optionally substituted by lower alkyl or by lower alkanoyl and the other is hydrogen, lower alkyl, or carbamoyl optionally substituted by lower alkyl or by lower alkanoyl, and R.sub.3 represents hydrogen or lower alkyl, have anticonvulsive properties and can be used as anticonvulsives. They are manufactured as follows: in a compound of the formula ##STR2## in which R.sub.1 ' represents a radical R.sub.1 or X and R.sub.2 ' represents a radical X, or R.sub.1 ' represents a radical X and R.sub.2 ' represents a radical R.sub.2, where X represents a group that can be converted into carbamoyl that optionally is mono- or di-substituted by lower alkyl or monosubstituted by lower alkanoyl, the radical X or the radicals X is/are converted into carbamoyl that optionally is mono- or di-substituted by lower alkyl or monosubstituted by lower alkanoyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.