Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
US4851439A · kind A · utility
Inventors
Key dates
| Filing date | Dec 30, 1985 |
| Grant date | Jul 25, 1989 |
| Priority date | — |
| Expiry date | Dec 30, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fumaric acid derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a metallic cation, and PA1 R.sub.2 is a saturated or unsaturated aliphatic C.sub.6 -C.sub.24 alkyl group, psoralen-9-yl, retinyl, .alpha.-tocopheryl (vitamin E), calciferyl, corticosteroid-21-yl or monosaccharid-.omega.-yl; a group of fumaric acid derivatives based on glycerol, alkane diol or polyol molecules; and fumaric acid derivatives of the forumla ##STR2## wherein n is an interger from 30 to 260, PA1 R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, PA1 R.sub.4 is one of the R.sub.3 groups and n is the number of molecule repetitions, processes for their production and compositions containing same are described. These compounds are useful as drugs for the treatment of cryptogenically-caused diseases and have antisporiatic as well as antimicrobial action.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.