Monoclonal antibody that specifically binds to disialosyl Le.sup.a
US4851511A · kind A · utility
55Cited by
2References
13Claims
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Key dates
| Filing date | Jan 30, 1986 |
| Grant date | Jul 25, 1989 |
| Priority date | — |
| Expiry date | Jan 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/861
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disialosyl Le.sup.a (IV.sup.3 NeuAcIII.sup.6 NeuAcIII.sup.4 FucLc.sub.4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861)secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Le.sup.a. The disialosyl Le.sup.a antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Le.sup.a antigen level, which subsequently decreased after surgical tumor removal.
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