Process for the preparation of a 4,5-tri or tetramethylene-4-isothiazoline-3-one
US4851541A · kind A · utility
8Cited by
7References
3Claims
0Family size
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Key dates
| Filing date | Jun 5, 1986 |
| Grant date | Jul 25, 1989 |
| Priority date | — |
| Expiry date | Jun 5, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing a 4,5-tri or tetramethylene-4-isothiazoline-3-one comprises cyclizing a 2-alkyl or aralkyl thio-1-cycloalkene-1-carboxamide in the form of its sulfoxide in an organic solvent in the presence of a acid chloride and adding to the resulting 4,5-tri or tetramethylene-4-isothiazoline-3-one hydrochloride a mineral or organic base or water so as to free the 4,5-tri or tetramethylene-4-isothiazoline-3-one in the form of a free base.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.