Transdermal administration of a systemic active agent to a premature neonatal infant
US4853227A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1987 |
| Grant date | Aug 1, 1989 |
| Priority date | — |
| Expiry date | Oct 23, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7023
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating a premature neonatal infant of a gestational age between about 24 and about 35 weeks with a pharmaceutically acceptable, systemically active, substantially skin compatible, water-soluble neonatal therapeutic agent having a molecular weight below about 5000, and which agent is substantially non-transmissable through normal mature intact human skin, comprising: (a) applying to the intact neonatal skin of said infant a transdermal device comprising (i) a backing member, (ii) a substantially shape retaining hydrogel reservoir having a water content of between about 5 percent and about 95 percent preferably between 10 percent and 80 percent by weight of said reservoir and containing an effective amount of said agent, (iii) a skin contacting surface of predetermined area, and (iv) means for maintaining said reservoir in material transmitting relationship to said skin; (b) maintaining said skin contacting surface of said device in material transmitting relationship to said intact neonatal skin of the infant for an extended period of time; and (c) delivering said agent through the intact neonatal skin in a controlled continuous manner such that the blood plasma level o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.