Derivatives of quinuclidine

US4855290A · kind A · utility

Assignee

• State of Israel, Represented by Prime Minister's Office, Israel Institute for Biological Research · IL

Inventors

• Abraham Fisher · Haifa, IL
• Ishai Karton · Nes Ziona, IL
• Eliahu Heldman · Rehovot, IL
• Aharon Levy · Beit Hanan, IL
• Yona Grunfeld · Rehovot, IL

Key dates

• Filing date: Apr 18, 1986
• Grant date: Aug 8, 1989
• Expiry date: Apr 18, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Quinuclidine derivatives having the general formula (I) ##STR1## and geometrical isomers, enantiomers, diastereoisomers, racemates and/or acid addition salts thereof, wherein Z represents the group >CR.sup.1 R.sup.2 or two hydrogen atoms; and R.sup.1 and R.sup.2, which may be identical or different, are each alkyl, cyclopentyl, cyclohexyl, aryl, or diarylmethylol, or alkyl which is substituted by one or more aryl groups, or one of R.sup.1 and R.sup.2 may be hydrogen.