Preparation of amino acid derivatives
US4855455A · kind A · utility
2Cited by
2References
19Claims
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Assignee
Inventor
Key dates
| Filing date | Jan 22, 1988 |
| Grant date | Aug 8, 1989 |
| Priority date | — |
| Expiry date | Jan 22, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D331/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A hydroxy-carboxylate ester is converted to an amino-acid-amide by replacement of the --OH group with --N.sub.3, via, e.g., CH.sub.3 SO.sub.2 Cl and NaN.sub.3 ; reacting with amine to convert the ester to amide; and hydrogenating --N.sub.3 to --NH.sub.2. The present process alleviates the conventional use of blocking-deblocking procedures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.