Method for preserving liposomes
US4857319A · kind A · utility
110Cited by
11References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 21, 1987 |
| Grant date | Aug 15, 1989 |
| Priority date | — |
| Expiry date | May 21, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for preserving liposomes includes freeze-drying liposomes most preferably having an average size of about 50 nm to 100 nm with a disaccharide preserving agent being present both internally (with the encapsulated liposomal contents) and externally. The disaccharide component is in a weight ratio with respect to the lipid component of from at least about 0.1:1 to not greater than about 4:1 and is preferably trehalose. When the lyophilizates are reconstituted by rehydration, the resultant liposomes can retain up to 100% of the originally encapsulated contents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.