Process for obtaining D(+)-naproxen

US4857462A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Josef Maier · Eichstätt, DE
• Manfred Gloger · Weilheim, DE
• Detlef V. Hoerschelmann · Wielenbach, DE
• Jan Strejcek · Iffeldorf, DE
• Sebastian Heimerl · Tutzing, DE

Key dates

• Filing date: Oct 27, 1986
• Grant date: Aug 15, 1989
• Expiry date: Oct 27, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/40
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for obtaining D-2-(6-methoxy-2-naphthyl)-propionic acid from a mixture of D- and L-2-(6-methoxy-2-naphthyl)-propionic acid lower alkyl esters is provided by asymmetric hydrolysis of the L-ester with a microbial enzyme, separation of the 2-(6-methoxy-2-naphthyl)-propionic acid from the D-2-(6-methoxy-2-naphthyl)-propionic acid lower alkyl ester and saponification of the latter, wherein the saponification is carried out enzymatically with esterase from hog liver or from Pleurotus ostreatus.