Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents
US4857553A · kind A · utility
16Cited by
0References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 10, 1988 |
| Grant date | Aug 15, 1989 |
| Priority date | — |
| Expiry date | Aug 10, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/215
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the treatment of emesis in a mammal, which method comprises administering to said mammal an emesis inhibiting amount of a compound which depletes serotonin in the brain of mammals; among which are compounds having the formula: ##STR1## wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R.sup.1 and R.sup.2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof; two of the preferred compounds of the invention are fenfluramine and norfenfluramine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.