Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compounds
US4857660A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1988 |
| Grant date | Aug 15, 1989 |
| Priority date | — |
| Expiry date | Apr 22, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.