Clodronate-containing medicaments and a process for the preparation thereof

US4859472A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Fritz Demmer · Hirschberg, DE
• Berthold Stemmle · Burgdorf, DE

Key dates

• Filing date: Dec 17, 1987
• Grant date: Aug 22, 1989
• Expiry date: Dec 17, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a medicament containing 80 to 95% clodronate, 2 to 10% filling material and 1 to 10% lubricant. The present invention also provides a process for the production of a clodronate-containing medicament containing 80 to 95% clodronate, 2 to 10% filling material and 1 to 10% lubricant, wherein the dry components are mixed, moist granulated with an aqueous binding agent and the granulate obtained subsequently dried, a lubricant being additionally admixed with the final granulate in an amount of from 1 to 5% and the mixture thus obtained pressed into tablets or filled into capsules which have a rate of dissolving of >90% after 30 minutes.