Recombinant herpes simplex viruses, vaccines and methods
US4859587A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 25, 1986 |
| Grant date | Aug 22, 1989 |
| Priority date | — |
| Expiry date | Apr 25, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2730/10122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant herpes viruses useful as effective ingredients in vaccines against both virulent HSV-1 and HSV-2 are disclosed. Methods of preparing the recombinant viruses, vaccines incorporating the viruses, and methods of immunizing a human host by inoculation with the vaccines are also disclosed. The genomes of the recombinant viruses each comprise a mutant of the HSV-1 genome from which a portion thereof responsible for neurovirulence yet nonessential for growth is deleted. A gene from the HSV-2 genome responsible for coding an immunity-inducing glycoprotein is inserted in the mutant genome between the end points of deletion therein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.