Process for the preparation of stereoisomers of 1-aminoalkylphosphonic and phosphinic acids

US4859602A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Gerd Zimmermann · Eckental, DE
• Josef Maier · Eichstätt, DE
• Manfred Gloger · Weilheim, DE

Key dates

• Filing date: Sep 9, 1985
• Grant date: Aug 22, 1989
• Expiry date: Sep 9, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/001
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides a process for the preparation of the stereoisomers of 1-aminoalkylphosphonic acids and of 1-aminoalkylphosphinic acids by enzymatic resolution of their racemic N-acyl derivatives and subsequent deacylation, wherein the enzymatic resolution is carried out with penicillin G amidase.