Multiply substituted pyridine 1-oxide compounds which are useful in treating brain disorders

US4859663A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wilfried Greve · Rödermark, DE
• Ulrich Elben · Wiesbaden, DE
• Karl Lenhard Rudolph · Kelkheim, DE
• Ursula Schindler · Bad Soden, DE

Key dates

• Filing date: Dec 16, 1986
• Grant date: Aug 22, 1989
• Expiry date: Dec 16, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Multiply substituted pyridine 1-oxides of the formula I ##STR1## in which R.sup.1 and R.sup.2 are, in each case, identical or different and represent alkyl having 1 to 6 carbon atoms, PA0 R.sup.3 denotes hydrogen, and PA0 R.sup.4 denotes mercaptoalkyl having up to 4 carbon atoms, or PA0 R.sup.3 and R.sup.4 form, together with the nitrogen atom in the 4-position, a five- to seven-membered saturated heterocyclic ring which has up to 2 heteroatoms, the second heteroatom being oxygen, sulfur which can carry up to two oxygen atoms, or nitrogen in the form of the NR.sup.6 group, in which R.sup.6 is hydrogen, alkyl having up to 2 carbon atoms, phenylalkyl having up to 2 carbon atoms in the alkyl moiety or phenyl, and the phenyl rings in the two latter radicals can carry up to two identical or different substituents from the group comprising halogen and methoxy, and which ring is unsubstituted or carries up to two identical or different substituents from the group comprising hydroxy and alkyl having up to 2 carbon atoms, and PA0 X denotes the cyano or nitro group the or the group --CO--R.sup.5, in which R.sup.5 represents the amino, hydroxyl or an alkoxy group having up to 4 carbon atoms, …