Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone

US4859672A · kind A · utility

Assignee

• Rorer Pharmaceutical Corporation · US

Inventors

• Alfred P. Spada · Lansdale, US
• Henry F. Campbell · North Wales, US
• Donald E. Kuhla · Gales Ferry, US
• William L. Studt · Harleysville, US
• William C. Faith · Ambler, US
• Bruce F. Molino · Slingerlands, US

Key dates

• Filing date: Oct 29, 1986
• Grant date: Aug 22, 1989
• Expiry date: Oct 29, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure ##STR1## wherein: A is ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8, R.sub.10, R.sub.11, R.sub.12, R.sub.14, R.sub.15, R.sub.16, R.sub.17, R.sub.18, R.sub.19, R.sub.20, R.sub.21, R.sub.22, R.sub.23 and R.sub.24 are H, lower alkyl of 1-4 carbon atoms, phenyl, substituted phenyl, phenyl lower alkyl of 1-4 carbon atoms or substituted phenyl lower alkyl of 1-4 carbon atoms; PA2 wherein the substituted phenyl group is substituted by one or more of lower alkyl, lower alkoxy, amino, lower alkyl amino, lower alkyl mercapto, hydroxy, hydroxy lower alkyl, acetoxy, benzyloxy, phenoxy, lower alkyl sulfinyl or lower alkyl sulfonyl; PA2 R.sub.13 is H, lower alkyl of 1-4 carbon atoms, alkoxy lower alkyl of 1-4 carbon atoms, hydroxy lower alkyl of 1-5 carbon atoms, amino, carbamoyl, cyano, lower alkyl carbamoyl of 1-4 carbon atoms, formyl, amino lower alkyl of 1-4 carbon atoms, carboxy, carbalkoxy, or tetrazolyl; PA2 R.sub.3 and R.sub.4 together may form =O; PA2 R.sub.16 and R.sub.17 togeth…