2-Halogenated-8- and 1,8-substituted ergolenes
US4859682A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 21, 1987 |
| Grant date | Aug 22, 1989 |
| Priority date | — |
| Expiry date | Apr 21, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein X stands for a halogen; PA0 R stands for a C.sub.1-4 alkyl group and PA0 R" means a hydroxyl group; or PA0 R stands for an acyl or substituted acyl group and PA0 R" represents a halogen or an --OR' group, wherein PA0 R' stands for an acyl or substituted acyl group; or PA0 R stands for hydrogen and PA0 R" means a halogen or an --OR' group, wherein R' stands for an acyl or substituted acyl group; and the dotted line means a double bond between the 8-9 or 9-10 positions. The compounds of the formula (I) possess an antipsychotic and antihypoxic action and a negligable extrapyramidal side-effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.