Patent · US Expired

Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof

US4859768A · kind A · utility

11Cited by

2References

16Claims

0Family size

Assignee

Temple University-Of The Commonwealth System of Higher Education · US

Inventors

Robert J. Suhadolnik · Roslyn, US
Wolfgang Pfleiderer · Konstanz, DE

Key dates

Filing date	Jan 11, 1988
Grant date	Aug 22, 1989
Priority date	—
Expiry date	Jan 11, 2008

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H23/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective antiviral agents for pharmaceutical and agricultural use. They are particularly useful in inhibiting replication of tobacco mosaic virus. Novel synthetic analogs have the following formulae wherein m=0, 1, 2 and 3 and n=0, 1, 2, 3 or 4: ##STR1## The invention described herein was supported by National Institutes of Health Grant GM-26134 and National Science Foundation Grant PCM-8111752.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.