Process for the production of nourseothricine and its adsorbate

US4861715A · kind A · utility

Assignee

• VEB Jenapharm · DE

Inventors

• Friedrich Bergter · Jena, DE
• Harald Bocker · Jena, DE
• Ernst-Joachim Bormann · Jena, DE
• Wolfgang Forberg · Jena, DE
• Heinz Fricke · Jena, DE
• Udo Grafe · Jena, DE
• Hans-Helmut Grosse · Jena, DE
• Ingeborg Heller · Jena, DE
• Matthias Hilliger · Jena, DE
• Wolf Junne · Jena, DE
• Hellmut Linde · Jena, DE
• Michael Menner · Jena, DE
• Klaus-Dieter Menzel · Apolda, DE
• Peter-Jurger Muller · Jena, DE
• Gunter Plonka · Jena, DE
• Hans D. Pohl · Jena, DE
• Jorg Schneider · Wezembeek-Oppem, BE
• Heinz Thrum · Jena, DE

Key dates

• Filing date: Jan 20, 1984
• Grant date: Aug 29, 1989
• Expiry date: Jan 20, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/57
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process is disclosed for the fermentative production of the ergotropically effective antibiotic nourseothricin, with which, using different carbohydrate sources and suitable inorganic and organic nitrogen sources as well as different mineral salts, with or without addition of stock substances of the respiratory chain or the intracellular amino acid transport, and through influencing the phosphate substance exchange and avoidance of further limitations with regulated acidity conditions, high concentrations of this antibiotic are cultivated in the culture solution. The recovery of the active substance in the culture solution follows either by chromatographic techniques in the form of salts or through addition of a physiologically compatible adsorbent as mycelium-containing nourseothricin-adsorbate, which preferably can be added to the dosaging of mixed feed agents.