Method of treating tumors using tetracyclo compounds
US4861774A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 30, 1986 |
| Grant date | Aug 29, 1989 |
| Priority date | — |
| Expiry date | Dec 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl, PA0 R.sup.2 is hydroxy, alkoxy, or protected hydroxy, PA0 R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, or PA0 R.sup.3 and R.sup.4 are combined together to form methylene or oxo, PA0 R.sup.5 is hydroxy, alkoxy or protected hydroxy, and PA0 R.sup.6 is hydrogen, imino-protective group or alkyl, and pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.