1H-pyrido-(2,3-b) (1,4)-thiazines

US4861878A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerd Fengler · Krefeld, DE
• Alexander Klausener · Neunburg vorm Wald, DE
• Hans-Josef Buysch · Krefeld, DE
• Mithat Mardin · Wuppertal, DE
• Bernhard Pelster · Sankt Augustin, DE

Key dates

• Filing date: Nov 6, 1986
• Grant date: Aug 29, 1989
• Expiry date: Nov 6, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New potent lipoxygenase inhibitors which are 1H-pyrido-[2,3-b][1,4] thiazines are disclosed. The new thiazines are of the formula ##STR1## in which R.sup.1 denotes hydrogen, halogen, optionally substituted alkyl or alkoxy or the group ##STR2## in which R.sup.5 and R.sup.6 are identical or different and denote hydrogen, optionally substituted alkyl or aryl, or can be linked to form a 5- or 6-membered heterocyclic ring, PA0 R.sup.2 and R.sup.3 are identical or different and denote hydrogen or optionally substituted alkyl or alkoxy and PA0 R.sup.4 denotes hydroxyl, the group ##STR3## in which R.sup.5 and R.sup.6 have the abovementioned meaning, or, in the case where R.sup.3 denotes hydrogen or optionally substituted alkoxy, also denotes optionally substituted alkoxy.