Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3') q
US4861886A · kind A · utility
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10Claims
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Key dates
| Filing date | Jul 6, 1988 |
| Grant date | Aug 29, 1989 |
| Priority date | — |
| Expiry date | Jul 6, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D497/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for isomerization of trans-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof, which comprises isomerizing said trans-form quinuclidine or acid addition salts thereof to cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof in the presence of at least one acid catalyst selected from the group consisting of an organic sulfuric acid, a halide functioning as a Lewis acid, and sulfuric acid.
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