Extracorporeal reactors containing immobilized species
US4863611A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 30, 1987 |
| Grant date | Sep 5, 1989 |
| Priority date | — |
| Expiry date | Apr 30, 2007 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J20/3274
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
An apparatus for removing material from a biological solution consisting of a reactor chamber having an inlet and an outlet, a bioactive compound immobilized on particular supports within the reactor, means for retaining the particular supports within the reactor, means for recirculating the solution and the supports at a high flow rate within the reactor, and means for agitating or dispersing the recirculating solution-support mixture throughout the reactor chamber so as to prevent packing of the supports while not subjecting the solution to excessive or damaging forces. In the given example, an apparatus for the extracorporeal removal of heparin from blood is provided. Heparinase is immobilized on cross-linked agarose beads recirculated at a high flow rate through the reactor. Agitation of the blood-bead mixture sufficient to prevent packing of the beads within the reactor chamber is provided by means of a series of openings in the recirculation tube dispersing the mixture throughout the chamber.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.