Sterilization of compositions of limited stability
US4863714A · kind A · utility
17Cited by
2References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 5, 1987 |
| Grant date | Sep 5, 1989 |
| Priority date | — |
| Expiry date | Feb 5, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/90
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for producing sterile drug formulations, where drugs are thermolabile and pH sensitive. The method provides formulating the drug with a physiologically acceptable inorganic or organic acidic buffer for buffering at a pH in excess of 6, reducing the pH below about 5 by adding carbon dioxide, and heat sterilizing the formulation in a gas permeable sealed container. The resulting formulation is substantially free of degraded drug and at the desired physiologically acceptable pH. Also, formulations are provided which do not cause clotting during administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.