Liposome compositions of anthracycline derivatives
US4863739A · kind A · utility
17Cited by
17References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 19, 1987 |
| Grant date | Sep 5, 1989 |
| Priority date | — |
| Expiry date | May 19, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are liposomal antitumor compositions having improved pharmacological characteristics. Liposomes described herein are formed through the incorporation of a particular class of anthracyclines, the 4-demethoxy-3'-desamino-2'-iodo analogs, shown to have extremely high incorporatio efficiencies of greater than 95%. These liposomes demonstrate an improved antitumor efficacy, with much reduced toxicity, against accepted tumor models, and further exhibit excellent stability upon storage, for example, in the form of a dried powder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.