Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them

US4863949A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Herbert Simon · Lampertheim, DE
• Helmut Michel · Mannheim, DE
• Wolfgang Bartsch · Viernheim, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Sep 21, 1987
• Grant date: Sep 5, 1989
• Expiry date: Sep 21, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of the general formula: ##STR1## wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic radical, A is a straight-chained or branched alkylene chain containing up to 8 carbon atoms, a --CH.sub.2 -- group of which can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms, B is a straight-chained mono- or bicyclic, optionally branched, saturated or unsaturated alkylene chain containing up to 12 carbon atoms, a --CH.sub.2 -- group of which can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms and/or up to two --CH.sub.2 -- groups of which can be replaced by an oxygen or a sulphur atom or by an --S(.dbd.O) or --S(.dbd.O).sub.2 group, X is a valency bond, an oxygen atom or an --NR.sup.1 group, in which R.sup.1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated alkyl or nitroxyalkyl radical containing up to 6 carbon atoms or R.sup.1, together with the nitrogen atom of the --NR.sup.1 -- group and a --CH.sub.2 -- group of the chain B, can form a heteroaliphatic ring containing 4 to 6 carbon atoms and n is 1, 2 or 3; and the physiologically acceptable salts thereof. The p…