Method for the stabilization of deferoxamine to chelate free ions in physiological fluid
US4863964A · kind A · utility
27Cited by
7References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 20, 1987 |
| Grant date | Sep 5, 1989 |
| Priority date | — |
| Expiry date | Aug 20, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/62
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccarides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.